| ncRNA name | Nox4 siRNA |
| ncRNA Category | siRNA |
| Disease name | diabetic retinopathy (DR) |
| Species | Homo sapiens |
| Tissues/Cell_line | human retinal endothelial cells (HRECs) |
| Methods | RT-PCR, Western blot, siRNA transfection |
| Expression pattern | associated |
| Functional description | In HG‑treated cells, Nox4 expression was upregulated at the mRNA and protein levels, and inhibition of Nox4 by GKT137831 or knockdown of expression by siRNA Nox4 significantly reduced ROS levels and cell death. |
| PubMed ID | 30431086 |
| Year | 2019 |
| Title | Activation of the Notch‑Nox4‑reactive oxygen species signaling pathway induces cell death in high glucose‑treated human retinal endothelial cells. |
| Drug-related ncRNA | NO |
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